Anagrams of: TOPKNOT_

• An unfavorable card or token, or undesirable or worthless item used as a prize in a contest or game show (such as Let's Make a Deal).

• A feeling of a drug taking hold.

• To hit hard .

• To make (someone) sleepy or delirious, to put into a stupor .

• (usually followed by “out”) To become exhausted, sleepy or delirious.

• headdress consisting of a decorative ribbon or bow worn in the hair

• showy crest or knot of hair or feathers

• a correctional institution used to detain persons who are in the lawful custody of the government (either accused persons awaiting trial or convicted persons serving a sentence)

• wasting time

• small and remote and insignificant

• making great mental demands; hard to comprehend or solve or believe

• used of old persons or old trees; covered with knobs or knots

• highly complex or intricate and occasionally devious

• tangled in knots or snarls

• headdress consisting of a decorative ribbon or bow worn in the hair

• showy crest or knot of hair or feathers

• the facility where wild animals are housed for exhibition

• a common venereal disease caused by the treponema pallidum spirochete; symptoms change through progressive stages; can be congenital (transmitted through the placenta)

• a contagious disease characterized by purulent skin eruptions that may leave pock marks

• someone regarded as eccentric or crazy and standing out from a group