To empty or unload, as the vessels of the human system, by bloodletting or by medicine.
Example: "Certain medications can deplete vitamin d."
To reduce by destroying or consuming the vital powers of; to exhaust, as a country of its strength or resources, a treasury of money, etc.
Used up, expended; of which nothing is left.
Example: "The depleted aerosol can would spray no more since there was no propellant left."